- Nicotinamide adenine dinucleotide (NAD+) is an essential compound for optimal function of all systems in the body
- Aging is accompanied by a universal decrease in NAD+ levels in the body despite the body’s need for NAD+ increasing with age
- Many age-related conditions have been linked to NAD+ deficiency
- Improving NAD+ production and replenishing NAD+ levels in the body may promote health and longevity
Actions to Consider
- You can replenish your NAD+ levels by taking a supplement like nicotinamide riboside (NR) or nicotinamide mononucleotide (NMN)
- The amino acid tryptophan is another natural precursor of NAD+. You can get it as a supplement or just eat tryptophan-rich products like meat, poultry, eggs, dairy products, spinach, seeds, and nuts. In general, any protein-rich food is a good source of tryptophan.
Is NAD+ one of your body’s universal anti-aging molecules? Studies suggest it might be
Nicotinamide adenine dinucleotide (NAD+) is a vital compound in the human body, it’s needed for nearly every important molecular process. It takes part in regulating energy metabolism, works as a messenger molecule, regulates gene expression by tweaking sirtuin activity, and much more.
Yet to our detriment, the body’s levels of NAD+ go down with aging, and this tendency triggers a wide range of age-related issues.
What is this study about?
This study is a detailed overview of the production, cellular functions, therapeutic potential, and possible anti-aging applications of NAD+. Published in 2018 in the F1000 Research journal, it contains data from the majority NAD-related studies available to date.
What is NAD+, and why is it so important?
NAD+ is a cofactor–a compound that’s necessary for enzymes to work properly. Without NAD+, some enzymes work much slower while others can’t work at all.
NAD+ is essential for many vital processes in the body, including
- Anaerobic (oxygen-independent) breakdown of glucose for energy
- Aerobic (oxygen-dependent) usage of glucose
- Oxidizing fatty acids
- Regulating the function of sirtuins, proteins that take part in many aging-related changes, stress response, circadian rhythms, and other aspects of optimal cell functioning
- Working as a neurotransmitter (signaling molecule) between neurons and other cells
Where is our NAD+ when we need it most?
As we age, the body becomes less efficient in producing NAD+, and this leads to a significant decline in its levels. At the same time, the body’s need for NAD+ goes up with the years. Not great for our longevity goals.
As NAD+ levels decline, the enzymes that it regulates function worse and worse, increasing one’s risk of developing all sorts of health conditions, for example:
- Non-alcoholic fatty liver disease
- Alzheimer’s disease
- Degradation of the eye’s retina
Luckily, studies have reported that supplementing with NAD+ precursors like nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN) is effective in reducing the signs of age-related NAD+ decline.
All in all, it seems that NAD+ is an effective anti-aging compound, and that’s why its precursors work so well in this matter.
Although the problem of aging is huge and multi-faceted, we already know the solutions to some of its aspects. Supporting one’s NAD+ levels is one of them, and studies suggest this approach is fairly effective both for health and for longevity.
Link to the study: